Metabolic
MOTS-c
Mitochondrial-Derived Peptide
Scientific Overview
MOTS-c is a peptide encoded in mitochondrial 12S rRNA. Research examines its proposed roles in metabolic homeostasis, muscle and fat metabolism, and mitochondrial-nuclear communication.
Mechanism focus: Preclinical studies explore AMPK-related metabolic signaling and cellular responses to metabolic stress. Human evidence is earlier-stage than the cell and animal literature.
Research Use Cases
- Mitochondrial-derived peptide assays
- Metabolic homeostasis models
- Cellular stress-signaling studies
- Comparison with other mitochondrial peptides
Use-Case Study Notations
- Case-study notation (preclinical): the original description linked MOTS-c to metabolic homeostasis in cell and mouse models.
- Case-study notation: later reviews discuss MOTS-c as a mitochondrial-derived peptide with metabolic research interest.
- This page does not present clinical outcome claims.
Selected Studies (English, PubMed)
Five peer-reviewed sources indexed on PubMed. Links open the PubMed record for verification.
- The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance β PubMed 25738459
- MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism β PubMed 27216708
- MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation β PubMed 36761202
- MOTS-c Functionally Prevents Metabolic Disorders β PubMed 36677050
- MOTS-c improves intrinsic muscle mitochondrial bioenergetic health and efficiency in a PGC-1Ξ±/AMPK-dependent manner β PubMed 41520850
Related compounds
Research Use Only. This page is educational and intended for laboratory research context. Products are not for human consumption and are not intended to diagnose, treat, cure, or prevent any disease.